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This review concentrates on the function, molecular determinants and pharmacology of ion channels that reside in the sarcolemma and that contribute to the distinct phases of the altered transmembrane action potentials of myocytes surviving in the infarcted heart. The discussion will be divided into two general categories. First, substrate findings will be discussed and linked to the time course of arrhythmias as they are known to occur in experimental myocardial infarction models. This section will be followed by a discussion of the ion channel changes in myocytes remote from the infarct area, that is, in areas of regional hypertrophy. Finally, what is known about the molecular determinants of ion channels of myocytes from these diseased hearts is presented.

Various arrhythmic phases occur after the onset of experimentally produced myocardial ischemia and infarction in animal hearts. Current hypotheses maintain that the mechanisms of some of these cardiac arrhythmias can be understood in terms of the alterations in cellular electrical activity in specific regions of the heart post myocardial infarction (MI) (see [1] ). For example, in hearts of large animals, acute coronary artery occlusion results in rapid ventricular arrhythmias (ventricular tachycardias and fibrillation) (acute phase). It is unlikely that chronic or persistent changes in ion channel function underlie these acute arrhythmias. Over the following 24–48 h (subacute phase of infarction) post occlusion, delayed spontaneous arrhythmias of ventricular origin (subendocardial Purkinje) occur in experimental models and may have counterparts in humans [2–4] . During the healing (days, weeks) or healed (months) infarct phase, sustained ventricular tachycardias are inducible in both animal and human hearts suggesting that the reentrant substrate is present. The site of origin of the ventricular arrhythmias in these hearts depends on the location of the surviving cells overlying the infarcted region. In one canine model, these reentrant arrhythmias have been mapped to an area described as the epicardial border zone [1] .

Numerous studies have described the specific changes in action potential (AP) configuration that occur in the canine subendocardial Purkinje fiber and the subepicardial ventricular fiber postcoronary artery occlusion. Generally, by 24–48 h after total coronary artery occlusion the APs of the subendocardial Purkinje fibers show reduced resting potentials and maximal action potential upstroke velocity (V̇ max ), as well as an increase in total time of repolarization. On the other hand, the cells of the epicardial border zone of the canine infarction model show a reduction in V̇ max , and a shortening and triangularization of the action potential by 5 days after total artery occlusion. By 14 days post occlusion further shortening of the AP occurs. Then by the time of the healed infarct (2 months), AP voltage profiles have returned to nearly normal [5] suggesting the presence of a process that might be termed ‘reverse remodeling’ ( Fig. 1 ). In addition, changes in conduction of the impulse at various times after coronary artery occlusion as well as the altered refractoriness of the tissue in the infarcted myocardium have been documented. Electrical changes at the level of the myocyte and the role they play in providing the substrate for inducible reentrant arrhythmias have been reviewed [1] .

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Businesses should look into new ways to engage customers with Groups , alongside their Page and advertising efforts.

The popular Canadian skincare company Deciem is a great example of a brand who is benefiting from Facebook Groups. In the group “ DECIEM ENTHUSIASTS ,” customers share product reviews, skincare regimens (which always involve Deciem products), advice, and company news (such as the much-talked-about firing of a Co-CEO).

This is the single most important piece of advice in this list. Everything about “meaningful interactions” boils down to creating quality content that people actually want to see. And how do you know what people want to see? By Jenny Women’s Pisa Closed Toe Ballet Flats 85 UK Blau Blau Fucile buy cheap pay with visa KMXv9N
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Quality content should already spark emotion in your followers. But, imagery and captions are important factors in engagement as well. Check out this post that Hootsuite shared to their Facebook page:

This post did well on Facebook because:

Another way to prompt engagement and comments from followers is to ask questions. In the post below, we asked readers what books they would recommend.

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But now that Facebook is deprioritizing content from brands and publishers, these skills will be more important than ever. Businesses must know how to target the right audiences to ensure their advertising dollars go further.

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In the official press release, Adam Mosseri wrote, “Many creators who post videos on Facebook prompt discussion among their followers, as do posts from celebrities. ” You could interpret this literally, but I’m willing to guess that the majority of brands on Facebook don’t have access to celeb product promos.

as do posts from celebrities.

Enter the influencer—“regular” people like you and me who happen to have large followings on social media and who have worked hard to gain the trust of their followers. Getting an influencer to post to their page on your brand’s behalf could very well lead to increased engagement and followers for you because, if the content is coming from someone people trust, it appears more authentic. Facebook has noted that it will show more posts from “publishers the community finds trustworthy.”

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